A influência da nanoencapsulação do meloxicam na farmacocinética de ratos wistar machos e fêmeas

Abstract

Meloxicam (MLX) is a drug that exhibits promising responses when evaluated for the treatment of central nervous system (CNS) diseases in in vitro assays. However, it faces technological limitations due to its low solubility and cerebral bioavailability. These limitations can be addressed by employing nanoencapsulation, given that polymeric nanocapsules (NCs) increase drug bioavailability and solubility, and reduce adverse effects. MLX shows pharmacokinetic differences between male and female rats, such as the area under the curve (AUC). This study aimed to investigate the plasma pharmacokinetics of MLX-containing NCs with different coatings in male and female rats. [...] Our data suggest that nanoencapsulation improves pharmacokinetic aspects of MLX and brain targeting, and reinforce the importance of considering sex differences when developing new drug delivery systems. Further studies are needed for better understanding.